[et_pb_section fb_built=”1″ _builder_version=”4.27.8″ background_enable_color=”off” custom_margin=”||-65px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”-42px|auto||auto||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#B59A5B” text_letter_spacing=”2.5px” global_colors_info=”{}”]<\/p>\n
CTE BIOLOGICS<\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.8″ text_font=”Cormorant Garamond|600|||||||” text_font_size=”64px” text_line_height=”1.08em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” custom_margin=”-26px|auto||auto||” custom_padding=”9px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#B59A5B” _builder_version=”4.27.8″ _module_preset=”default” max_width=”4%” module_alignment=”left” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#252B30″ text_font_size=”20px” text_line_height=”1.6em” max_width=”70%” module_alignment=”left” custom_margin=”-23px|||||” custom_padding=”0px|||||” global_colors_info=”{}”]<\/p>\n CTE Biologics is developing an investigational regenerative medicine program focused on the neurological consequences associated with repetitive head trauma.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.8″ _module_preset=”default” background_color=”#0B1F33″ custom_padding=”2px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#B59A5B” text_font_size=”14px” text_letter_spacing=”2.5px” global_colors_info=”{}”]<\/p>\n THE PROBLEM<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” text_text_color=”#F7F6F2″ text_font_size=”32px” text_line_height=”1.15em” header_font=”–et_global_heading_font|600|||||||” header_font_size=”32px” header_line_height=”1.15em” header_2_font=”–et_global_heading_font|–et_global_heading_font_weight|||||||” header_2_font_size=”42px” header_2_line_height=”1.5em” header_3_font=”–et_global_heading_font|600|||||||” header_3_font_size=”45px” custom_margin=”-23px|||||” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#F7F6F2″ text_font_size=”18px” width=”69%” custom_margin=”-32px|||||” custom_padding=”18px|||||” global_colors_info=”{}”]<\/p>\n Repetitive head impacts are not confined to a single sport, profession, or population. Years of repeated head impacts may occur among athletes, military personnel, first responders, and others whose lives or occupations expose them to repetitive brain trauma.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.8″ _module_preset=”default” background_color=”#F7F6F2″ custom_margin=”0px||||false|false” custom_padding=”11px||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#B59A5B” _builder_version=”4.27.8″ _module_preset=”default” max_width=”4%” module_alignment=”left” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|–et_global_heading_font_weight|||||||” text_text_color=”#B59A5B” text_font_size=”14px” text_letter_spacing=”2.5px” width=”65%” custom_margin=”-57px|||||” custom_padding=”0px|||||” global_colors_info=”{}”]<\/p>\n THE EXPOSURE<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_text_color=”#314B61″ text_font_size=”32px” text_line_height=”1.15em” min_height=”54px” custom_margin=”-66px|||||” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”20px” text_line_height=”1.6em” width=”65%” custom_margin=”-13px|||||” global_colors_info=”{}”]<\/p>\n A history of repetitive head impacts may begin long before symptoms appear. Exposure can accumulate through years of participation in contact and combat sports, military training or service, and other activities involving repeated impacts to the head.<\/span><\/p>\n Not every head impact produces a concussion, and exposure to repetitive head impacts does not by itself establish a diagnosis of CTE. Understanding the nature, frequency, duration, and timing of exposure is part of understanding the clinical history.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#B59A5B” global_colors_info=”{}”]<\/p>\n CONTACT SPORTS<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#B59A5B” global_colors_info=”{}”]<\/p>\n COMBAT SPORTS<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#B59A5B” global_colors_info=”{}”]<\/p>\n MILITARY<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|–et_global_heading_font_weight|||||||” text_text_color=”#B59A5B” global_colors_info=”{}”]<\/p>\n OTHER EXPOSURES<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.8″ _module_preset=”default” custom_margin=”-34px|auto||auto||” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#252B30″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Football [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#252B30″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Boxing<\/span> [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#252B30″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Training<\/span> [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#252B30″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Occupational<\/span> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.8″ _module_preset=”default” background_color=”#0B1F33″ custom_margin=”-59px|||||” custom_padding=”2px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#B59A5B” text_font_size=”14px” text_letter_spacing=”2.5px” global_colors_info=”{}”]<\/p>\n THE DISEASE<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” text_text_color=”#F7F6F2″ text_font_size=”32px” text_line_height=”1.15em” header_font=”–et_global_heading_font|600|||||||” header_font_size=”32px” header_line_height=”1.15em” header_2_font=”–et_global_heading_font|–et_global_heading_font_weight|||||||” header_2_font_size=”42px” header_2_line_height=”1.5em” header_3_font=”–et_global_heading_font|600|||||||” header_3_font_size=”45px” custom_margin=”-23px|||||” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#F7F6F2″ text_font_size=”18px” width=”69%” custom_margin=”-32px|||||” custom_padding=”18px|||||” global_colors_info=”{}”]<\/p>\n Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts. The disease is defined by characteristic changes in brain tissue that currently can be definitively identified only through neuropathologic examination after death.<\/span><\/p>\n That creates a fundamental challenge for researchers studying CTE in living people: how can individuals with a relevant history and clinical presentation be identified for careful study without treating exposure or symptoms alone as proof of the disease?<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.8″ background_enable_color=”off” custom_margin=”||-65px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”-51px|auto||auto||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#B59A5B” text_letter_spacing=”2.5px” global_colors_info=”{}”]<\/p>\n CTE & TES<\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.8″ text_font=”Cormorant Garamond|600|||||||” text_font_size=”64px” text_line_height=”1.08em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” custom_margin=”-26px|auto||auto||” custom_padding=”9px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#B59A5B” _builder_version=”4.27.8″ _module_preset=”default” max_width=”4%” module_alignment=”left” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#252B30″ text_font_size=”20px” text_line_height=”1.6em” max_width=”70%” module_alignment=”left” custom_margin=”-23px|324px||||” custom_padding=”0px|||||” global_colors_info=”{}”]<\/p>\n CTE describes the neuropathologic disease identified by characteristic changes in brain tissue. Traumatic Encephalopathy Syndrome (TES) is a clinical research framework developed to identify and study a pattern of cognitive and neurobehavioral features in living people with substantial exposure to repetitive head impacts. A diagnosis of TES does not establish that a person has CTE.<\/span><\/p>\n The distinction matters. Symptoms such as problems with memory, executive function, behavior, mood, or impulse control can have many causes. Evaluating a living person therefore requires more than a history of head impacts or the presence of symptoms\u2014it requires careful assessment of the clinical course and consideration of other conditions that may better explain the presentation.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.27.8″ _module_preset=”default” custom_margin=”|258px||auto||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#B59A5B” width=”89.3%” custom_padding=”||0px|||” global_colors_info=”{}”]<\/p>\n EXPOSURE<\/strong> [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#B59A5B” width=”96.5%” custom_padding=”|||0px||” global_colors_info=”{}”]<\/p>\n CLINICAL SYNDROME<\/strong> [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#B59A5B” width=”102.5%” custom_margin=”|||-115px||” global_colors_info=”{}”]<\/p>\n DISEASE<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” custom_margin=”-31px|auto||auto||” custom_padding=”30px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#E09900″ _builder_version=”4.27.8″ _module_preset=”default” width=”4%” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” min_height=”23px” custom_padding=”4px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” custom_margin=”-40px|||||” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” text_font_size=”32px” custom_margin=”-51px|||||” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.8″ _module_preset=”default” custom_margin=”-40px|auto||auto||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”20px” global_colors_info=”{}”]<\/p>\n The 2021 NINDS consensus criteria for Traumatic Encephalopathy Syndrome (TES) [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#B59A5B” global_colors_info=”{}”]<\/p>\n 01 \u2014 SUBSTANTIAL EXPOSURE<\/span><\/strong><\/span><\/p>\n A history of substantial repetitive head impacts <\/span> [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#B59A5B” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n 02<\/strong> \u2014<\/strong> CORE CLINICAL FEATURES<\/strong><\/span><\/span><\/p>\n The clinical presentation includes cognitive [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#B59A5B” global_colors_info=”{}”]<\/p>\n 03 \u2014 PROGRESSIVE COURSE [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.8″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#B59A5B” global_colors_info=”{}”]<\/p>\n 04 <\/strong>\u2014 DIFFERENTIAL EVALUATION<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" CTE BIOLOGICSRepetitive Brain Trauma Can Last a Lifetime. CTE Biologics is developing an investigational regenerative medicine program focused on the neurological consequences associated with repetitive head trauma.THE PROBLEMCTE Is Not a Football Problem.It Is a Repetitive Brain Trauma Problem.Repetitive head impacts are not confined to a single sport, profession, or population. Years of repeated head […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n This is an example page. It's different from a blog post because it will stay in one place and will show up in your site navigation (in most themes). Most people start with an About page that introduces them to potential site visitors. It might say something like this:<\/p>\n\n\n\n Hi there! I'm a bike messenger by day, aspiring actor by night, and this is my website. I live in Los Angeles, have a great dog named Jack, and I like piña coladas. (And gettin' caught in the rain.)<\/p>\n\n<\/blockquote>\n\n\n\n ...or something like this:<\/p>\n\n\n\n The XYZ Doohickey Company was founded in 1971, and has been providing quality doohickeys to the public ever since. Located in Gotham City, XYZ employs over 2,000 people and does all kinds of awesome things for the Gotham community.<\/p>\n\n<\/blockquote>\n\n\n\nRepetitive Brain Trauma <\/span>Can Last a Lifetime.<\/h1>\n
CTE Is Not a Football Problem.<\/strong><\/span>
It Is a Repetitive Brain Trauma Problem.<\/strong><\/span><\/h2>\nRepetitive Head Impacts Can Accumulate Over Years.<\/span><\/h2>\n
Hockey
Rugby
Soccer<\/p>\n
Mixed Martial Arts<\/span>
Martial Arts<\/span><\/p>\n
Combat<\/span>
Blast Exposure<\/span><\/p>\n
Recreational<\/span>
<\/p>\nChronic Traumatic Encephalopathy
Is a Neurodegenerative Disease.<\/span><\/h2>\nCTE and TES Are Related\u2014but
They Are Not the Same Thing.<\/span><\/h1>\n
Substantial history of
repetitive head impacts<\/span><\/p>\n
TES provides a framework
for studying clinical features
in living individuals<\/span><\/p>\n
CTE is definitively
identified through
neuropathologic
examination<\/span><\/p>\nUNDERSTANDING TES<\/span><\/h2>\n
A Clinical Framework for
Studying Living Individuals.<\/span><\/h2>\n
provide a research framework for evaluating living individuals with substantial exposure
to repetitive head impacts. The framework does not diagnose CTE. Instead, it brings
together exposure history, core clinical features, progression over time, and careful
consideration of other conditions that may better explain the presentation.<\/span><\/p>\n
is required. Exposure may arise through contact <\/span>
or collision sports, military service, or other <\/span>
activities involving repeated impacts to the head.<\/span><\/p>\n
impairment in episodic memory and\/or
executive functioning, neurobehavioral
dysregulation, or both. Objective assessment
can help characterize cognitive impairment.<\/span><\/p>\n
<\/span><\/strong>The clinical features must represent a progressive
course\u2014an important distinction from symptoms
that are transient, static, or better explained by
an isolated event.<\/span><\/p>\n
The clinical features must not be fully accounted
for by another neurologic, psychiatric, medical,
or other condition. Repetitive head-impact exposure
alone does not determine the explanation for an
individual’s symptoms.<\/span><\/p>\n\n\n
\n\n